Firstly, the structural formula of mercapto silica gel is (SiH2) n (SH) 2, which is composed of silicon, hydrogen, and hydrophobic groups. Thiol group is a strongly alkaline functional group that can react with different substances, while silicon and hydrogen endow thiol silica gel with good chemical and thermal stability. This special structure allows hydrophobic silica gel to be used in both conventional environments and exhibit excellent performance in high-temperature and high-pressure environments. Due to its good flexibility, durability and anti-aging properties, mercapto silica gel has been widely used in the electronic field. Hydrophobic silicone can be used as a packaging material for electronic components and a substrate material for microwave circulators. It not only protects the stability of the components, but also improves their reliability and durability. In addition, thiol functionalized silica gel has a wide range of applications in the medical field. It can be used as a biomedical material, such as for artificial joints, artificial blood vessels, and artificial organs, because it has good compatibility and biocompatibility with human tissues, reducing implantation time and post implantation complications. Finally, mercapto silicone can also be used for various building applications such as adhesives, sealants, and waterproofing agents. It can provide strong adhesion between building materials, prevent the infiltration and damage of water and moisture, and improve the durability and safety of building structures.