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SUQIAN DEWEI CHEMICAL CO.,LTD
SUQIAN DEWEI CHEMICAL CO.,LTD
17 YRS
Jiangsu, China
Main Products:
2-Methyl-5-Aminobenzenesulfonamide / 2-(4-Fluorophenyl)Thiophene / 2,4-Dichloropyrimidine / (5-(4-Fluorophenyl)Thiophen-2-yl)(5-iodo-2-Methylphenyl)Methanone / 2-((4-Cyanophenyl)Amino)Acetic Acid / N-Methoxycarbonyl-L-Tert-Leucine / Ethyl N-[3-Amino-4-(Methylamino)Benzoyl]-N-Pyridin-2-yl-beta-Alaninate / 3-Methyl-6-Nitro-1H-Indazole / 2-[[4-(2-Pyridinyl)Phenyl]Methylene]- Hydrazin / 2-[(5-Bromo-2-Methylphenyl)Methyl]-5-(4-Fluorophenyl)Thiophene / N-[2]Pyridyl-B-Alanin-Ethyl Ester / 2,3-Dimethyl-6-Nitro-2H-Indazole / (2R,3S)-3-(Tert-Butoxycarbonyl)Amino-1,2-Epoxy-4-Phenylbutane / (5-Bromo-2-Methylphenyl)(5-(4-Fluorophenyl)Thiophen-2-yl)Methanone / 2-(4-Fluorophenyl)-5-[(5-Iodo-2-Methylphenyl)Methyl]Thiophene / 4-(2-Pyridinyl)-Benzaldehyde / 2,3-Dimethyl-2H-Indazol-6-Amine / 4-(Methylamino)-3-Nitrobenzoic Acid / 3-Aminoacetophenone
Jiangsu, China
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3-Amino-6-methylbenzenesulfonam
2-(4-Fluorophenyl)Thiophene
2,4-Dichloropyrimidine
(5-(4-Fluorophenyl)Thiophen-2-yl)(5-iodo-2-Methylphenyl)Methanone
N-(4-Cyanophenyl)glycine
N-Methoxycarbonyl-L-Tert-Leucine
Ethyl N-[3-Amino-4-(Methylamino)Benzoyl]-N-Pyridin-2-yl-beta-Alaninate
3-Methyl-6-Nitro-1H-Indazole
2-[[4-(2-Pyridinyl)Phenyl]Methylene]- Hydrazin
2-[(5-Bromo-2-Methylphenyl)Methyl]-5-(4-Fluorophenyl)Thiophene
3-(Pyridin-2-ylamino)propanoate
2,3-Dimethyl-6-Nitro-2H-Indazole
Tert-Butyl[(1S)-1-(2R)-Oxiranyl-2-Phenylethyl]Carbamate
(5-Bromo-2-Methylphenyl)(5-(4-Fluorophenyl)Thiophen-2-yl)Methanone
2-(4-Fluorophenyl)-5-[(5-Iodo-2-Methylphenyl)Methyl]Thiophene
4-(2-Pyridinyl)-Benzaldehyde
2,3-Dimethyl-2H-Indazol-6-Amine
4-(Methylamino)-3-Nitrobenzoic Acid
3-Aminoacetophenone
2-(4-Fluorophenyl)Thiophene / CAS 58861-48-6
OVERVIEW
Uses
Packaging
| Pallets Packing | 20'FCL | 40'FCL | ||
| With | Without | With | Without | |
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25 KG/Fibre Drum
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Lead Time
14-30 days
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DESCRIPTION
2-(4-Fluorophenyl)Thiophene
Chinese name：2-(4-氟苯基)噻吩
CAS NO：58861-48-6
Molecular formula：C10H7FS
Molecular weight：178.22
Structural formula：
Application: Canagliflozin intermediate
Typical Properties
Summary
2- (4- fluorophenyl) thiophene is an intermediate for the synthesis of cangreijing. The Canagliflozin, trade name Invokana, was the first approved sodium glucose co transporter 2 (SGLT2) inhibitor, which was approved by the US FDA in March 2013 for the treatment of type 2 diabetes. Canagliflozin is one of the best clinical antidiabetic drugs in recent years. 2 - (4-fluorophenyl) thiophene is an important intermediate in the synthesis of this compound. 2- (4- fluorophenyl) thiophene is an important intermediate for the synthesis of antidiabetic drug Canagliflozin, so it is necessary to purify 2-, 4- fluorophenyl thiophene. It is a white solid at room temperature and a liquid at heating condition. Therefore, it is difficult to separate and purify. The traditional column chromatography separation method is cumbersome, time-consuming and not conducive to industrial production. At present, the literature on the synthesis of this compound only mentioned the separation of this compound by column chromatography, but the operation of this method is cumbersome and not easy to industrial production.
CAS No.
58861-48-6
Formula
C10H7FS
Molecular Mass
178.22600
Exact Mass
178.02500
PSA
28.24000
Logp
3.55420
IUPAC
2-(4-fluorophenyl)thiophene
SMILES
C1=CSC(=C1)C2=CC=C(C=C2)F
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Pharmaceutical Intermediates
Chemical and Physical Properties
Melting Point
51.0 to 55.0 °C
Density
1.201g/cm3
Boiling Point
252.316ºC
Flash Point
106.397ºC
Appearance
White powder
Acidity and Basicity
neutral reducibility
Export information
HS Code
29349990
Export Rebate
10%
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