3-iodophenol, as an organic synthesis and medicinal chemical intermediate, is commonly used in the preparation of biological hormones. In the synthesis and transformation, it mainly revolves around the iodine unit in its structure. Iodine atoms can be connected to alkynes, aryl groups, alkyl groups, etc. through coupling reactions. In addition, phenolic hydroxyl groups are prone to undergo alkylation reactions under alkaline conditions due to their acidity, resulting in ether compounds. Phenolic hydroxyl groups can also be converted into trifluoromethanesulfonic acid esters, and subsequent derivatization reactions can be carried out by utilizing the easily removable properties of trifluoromethanesulfonic acid esters.
CAS No.
626-02-8
Formula
C6H5IO
Molecular Mass
220.00800
Exact Mass
219.93900
PSA
20.23000
Logp
1.99680
IUPAC
3-iodophenol
Attribute classification
Matter Classification
organic
Category
Chemical and Physical Properties
Melting Point
42-44 °C(lit.)
Density
2.001 g/cm3
Boiling Point
190 °C / 100mmHg
Flash Point
>230 °F
Appearance
Yellow beige to gray crystalline powder, crystalline