CITICOLINE NEW PROCESS DEVELOPMENT R&D PATENT

INVENTOR: LIFEWE Biological Technology R&D Institute

Patent number: ZL 202310499712.1

Advantage:

1.Highly efficient enzymatic hydrolysis processing

2 .High conversion (Convert rate ≥90%，6 hours/Production cycle)

3.High purity with few by-products

Basic Information of Citicoline(CAS 987-78-0)

Name: Cytidine 5'-Diphosphocholine （or Citicoline, CDP choline）

CAS Number: 987-78-0

Molecular Formula: C14H26N4O11P2

Molecular Weight: 488.32

Synonyms: Nicolin, Brain Diphosphorylcholine （Choline Phosphate）, Cytidine Diphosphate Choline, Cytidine 5-DIPHOSPH, Difosfocin, etc.

Appearance: White crystalline powder

Melting Point: >185°C （dec.）

Specific Rotation: D25 +19.0° （c = 0.86 in H2O）

pKa: 4.4 （at 25℃）

Boiling Point: 851.4ºC at 760 mmHg

Solubility: Sparingly soluble in water

Chemical Properties:

1. Cytidine 5'-Diphosphocholine is a low-cost generic drug and a cerebral metabolism activator.
2. It can stabilize cell membranes by stimulating S-adenosyl-L-methionine, increase the dendritic complexity and spine density of motor neuron structures, improve the plasticity of non-damaged regional neurons, and promote functional recovery.
3. It can also increase the synthesis of phosphatidylcholine by upregulating choline cytidylyltransferase （CCT）, reducing the level of water-soluble phosphatidylcholine, inhibiting the activity of secretory phospholipase A2 （PLA2）, or inhibiting the activation of TNF-a/IL-1b and PLA2, thereby reducing the loss of phospholipids and repairing neuronal cell membranes.
4. It can increase the expression of anti-apoptotic factors such as Bcl-2 and inhibit the release of glutamate to reduce cell toxicity.
5. Cytidine 5'-Diphosphocholine can promote the rapid repair of damaged cell surfaces and mitochondrial membranes, maintain cell tightness and biological functions, and reduce the release of free fatty acids, thereby reducing the production of toxic oxygenated metabolites and free radicals.
6. It can increase plasma adrenaline levels, and stimulate the release of growth hormone, thyroid-stimulating hormone, and luteinizing hormone.

Preparation and Sources

1. It can be extracted from liver or yeast, or synthesized chemically.
2. The synthetic method involves reacting cytosine-5'-diphosphate with ethyleneimine to form cytosine-5'-diphosphate aminoethyl ester, which is then methylated with iodomethane.
3. Alternatively, cytosine-5'-phosphate amide can be directly condensed with phosphocholine ester to obtain the product.

Storage Conditions: Store in a dark, sealed place, with a shelf life of generally 24 months. Another version suggests storing at below -20°C.

Applications of Citicoline(CAS 987-78-0)

Cytidine 5'-Diphosphocholine is clinically used to treat various neurodegenerative diseases such as Alzheimer's disease, multiple sclerosis, and amyotrophic lateral sclerosis.

It is also used for consciousness disturbance after acute craniocerebral injury and brain surgery, and can gradually restore limb function in patients with hemiplegia caused by cerebral stroke.

It can also be used for functional and consciousness disturbances caused by other acute central nervous system injuries, as well as ischemic cerebrovascular diseases and vascular dementia.

Shaanxi Lifewe Bioengineering Co.,Ltd. (herein after referred to as the company) was founded in 2017, is located in Yangling National Agricultural Industry Demonstration Park, is a research and development, production and marketing Sales and services as a whole, the use of synthetic biology technology to produce bio-based chemicals and functional microorganisms and other products, committed to modern agriculture and human health industry development Innovative enterprises.

Keywords Related to Citicoline(CAS 987-78-0)

Cytidine 5'-Diphosph CAS 987-78-0; Citicoline Food Grade; Citicoline Supplier; Cytidine 5'-Diphosphocholine Manufacturer; China Citicoline; Citicoline 99%; Buy Citicoline; Citicoline Powder; Cytidine 5'-Diphosph; Citicoline Acid; Citicoline, CDP Choline (CDPC-H)

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