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Shanghai Jinhe BIO-PHARMACEUTICAL Co., Ltd.

24 YRS

Shanghai, China

CNY 3.4 Million

19980 m²

100-500 people

Main Products: Paclitaxel / Docetaxel Trihydrate / 10-Deacetylbaccatin III / Docetaxel / Cabazitaxel / Baccatine III

Shanghai, China

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Docetaxel Anhydrous 99.5% / CAS 114977-28-5

OVERVIEW

Packaging

5 KG/BOTTLE

Lead Time

14-30 days

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DESCRIPTION

Docetaxel Anhydrous 99.5%

Product Information
Product Name	Docetaxel Anhydrous 99.5%
Molecular Formula	C₄₃H₅₃NO₁₄(807.88)
Cas No.	114977-28-5
Quality standard	EP
Analysis	Standard
Assay(W/W)	98.0-102.0%
Purity(HPLC)	≥99.5%
Physical Control
Appearance	White crystalline powder
Identification	Conforms
Specific Optical Rotation	-40°～-47°
Water	≤3.0%
Chemical Control
Residue of solvents	Complies with ICH requirement
Residue on Ignition	NMT0.2%
Bacteria Endotoxins	0.4EU/MG
Heavy Metal	NMT20ppm
Chromatographic Impurities
Highest Individual Impurity	NMT0.1%
Unknown Impurity	NMT0.1%
Total Impurity	NMT0.5%
Microbiological Control
Total Aerobic Microbial Count	NMT 100cfu/g
S.Aureus & Aeruginosa	Negative
Salmonella & E.Coil	Negative
Storage
Store at 2-8°C, In well closed containers and protect from light and moisture.

Typical Properties

Docetaxel is an anticancer and antitumor drug. It can be used to study antibiotics, cell biology, cell signal transduction, neuroscience, apoptosis and cell cycle. Docetaxel is also used to study hair loss caused by docetaxel chemotherapy, prevention and treatment of non-small cell lung cancer in patients with contraindicated standard chemotherapy.

CAS No.

114977-28-5

Formula

C43H53NO14

Molecular Mass

807.8790

Exact Mass

807.34700

PSA

224.45000

Logp

3.65050

IUPAC

[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12-trihydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

SMILES

CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O

Matter Classification

organic

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